|
AIDS-
AIDS-Acquired Immune Deficiency Syndrome or Acquired Immunodeficiency
Syndrome (AIDS or Aids) is a collection of symptoms and infections
resulting from the specific damage to the immune system caused by
the human immunodeficiency virus in humans.
Antibodies (also known as immunoglobulins) are proteins
that are found in blood or other bodily fluids of vertebrates, and
are used by the immune system to identify and neutralize foreign
objects, such as bacteria and viruses. They are used to fight HIV
virus in the body.
An antigen or immunogen is a molecule that stimulates an
immune response. They can induce the generation of antibodies or
other protective substance. Antigens are usually proteins or polysaccharides.
These include parts (coats, capsules, cell walls, flagella, fimbrae,
and toxins) of bacteria, viruses, and other microorganisms.
ARVs - Antiretroviral drugs are medications for
the treatment of infection by retroviruses, primarily HIV. Different
classes of antiretroviral drugs act at different stages of the HIV
life cycle.
CBC-A complete blood count, also known as full
blood count (FBC) or full blood exam (FBE) or blood panel, is a
test requested by a doctor or other medical professional that gives
information about the cells in a patient's blood.
CD4 - Cluster of Differentiation 4 is a glycoprotein
expressed on the surface of T helper cells, regulatory T cells,
monocytes, macrophages, and dendritic cells. CD4 is also a primary
receptor used by HIV-1 to gain entry into host T cells.
CD8- Cluster of Differentiation 8 is a transmembrane
glycoprotein which serves as a co-receptor for the T cell receptor.
CD8 cytotoxic lymphocytes recognize and kill infected CD4+ T cells.
ELISA- Enzyme Linked Immunosorbent Assay, is a
typical HIV test, used detect HIV antibodies in serum, plasma, oral
fluid, dried blood spot or urine of patients.
HAART- Highly Active Anti-Retroviral Therapy is
a combination of several (typically three or four) antiretroviral
drugs.
HIV-Human Immunodeficiency Virus is the etiological
agent for AIDS. It is a retrovirus that primarily infects vital
organs of the human immune system such as CD4+ T cells (a subset
of T cells), macrophages and dendritic cells.
HPV- Human Papillomaviruses are a diverse group
of DNA-based viruses that infect the skin and mucous membranes of
humans and a variety of animals. Some HPV types may cause skin warts
(condylomas) while others may cause a subclinical infection resulting
in precancerous lesions. A group of about 30-40 HPVs is typically
transmitted through sexual contact and infect the anogenital region
resulting to genital warts. They are associated with diseases in
HIV patients
KSHV-Kaposi's Sarcoma-Associated Herpesvirus is
a gammaherpes virus that causes Kaposi’s Sacorma, one of the
major HIV/AIDS associated malignancies, it often appears as purplish
nodules on the skin, but can affect other organs, especially the
mouth, gastrointestinal tract, and lungs. It also causes High-grade
B cell lymphomas such as Burkitt's lymphoma.
MTCT – Mother to Child Transmission of HIV
is the transmission of the virus from the mother to the child which
can occur in utero during the last weeks of pregnancy and at childbirth.
In the absence of treatment, the transmission rate between the mother
to the child during pregnancy, labor and delivery is 25%
NNRTIs- Non-Nucleoside Reverse Transcriptase Inhibitors
are the third class of antiretroviral drugs that were developed.
NNRTIs block reverse transcriptase of HIV by binding at a different
site on the enzyme.
NARTIs or NRTIs - Nucleoside analog reverse transcriptase
inhibitors compose the first class of antiretroviral drugs developed.
NRTIs are analogues of the naturally occurring deoxynucleotides
needed to synthesize the viral DNA and they compete with the natural
deoxynucleotides for incorporation into the growing viral DNA chain.
NtARTIs or NtRTIs - Normally, nucleoside analogs
are converted into nucleotide analogs by the body. Taking nucleotide
analog reverse transcriptase inhibitors (NtARTIs or NtRTIs) directly
allows conversion steps to be skipped, causing less toxicity. They
have similar mode of action as NARTIs
OIs- Opportunistic Infections are infections caused
by organisms that usually do not cause disease in a person with
a healthy immune system, but can affect people with a poorly functioning
or suppressed immune system. Opportunistic infections are common
in people with AIDS.
Viral load is a measure of the severity of a viral
infection, and can be calculated by estimating the amount of virus
in an involved body fluid, for example, it can be given in RNA copies
per milliliter of blood plasma. Determination of viral load is part
of the therapy monitoring during chronic viral infections and in
immuno-compromised patients, e.g. after bone marrow or solid organ
transplantation and in patients infected with HIV-1, cytomegalovirus,
hepatitis B virus, and hepatitis C virus. |
|